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Alexey Onufriev
Professor,
Departments of Computer Science and Physics.
Graduate program in
Genetics, Bioinformatics, and Computational Biology.
Department of Biomedical Engineering and Mechanics.
2160C Torgersen Hall, Virginia Tech
Telephone: (540) - 231 - 4237
Email @cs.vt.edu : alexey
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Research
We develop and use theoretical approaches and computational methods to understand structure-function connection in biomolecular systems. Water, DNA, and 3D structure of the genome are our current favorites.
We also develop methods and algorithms that are used in computational design of new medicines.
My philosophy is that among the multitude of models of
a complex system that one can build, only the very simple, robust solutions
may have a chance to represent reality. Complex solutions with tens of
fitting parameters may sometimes be of great practical use, but often
misrepresent reality (the geocentric model of the Universe is one such
example). The same philosophy applies to computational methods we develop: simple, robust solutions are preferred. As with any theoretical work, close
contact with experimental groups is essential.
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